Quantifying lower back loading during activities of daily living in patients with ankylosing spondylitis
Whereas human beings have had cancer throughout recorded history, cancer is a very hot topic for the moment and cancer research is going through a paradigm shift. Traditionally, cancer research has been centered on transcriptional alterations and changes in protein coding genes. It is becoming clear now that cancer cells manage to deregulate almost any cell biological control mechanism in the cell, leading to the emergence of several exciting research areas and novel opportunities for therapeutic intervention. At this meeting, world leaders will cover following topics:
- Role of long non-coding RNAs and micro RNAs in cancer
- Alterations in RNA modifications / RNA metabolism / splicing in cancer
- Defects in ribosomal proteins and protein translation in cancer
- Alterations in post-translational modification of proteins in cancer (ubiquitination,…)
- Epigenetic changes and changes in the non-coding genome in cancer
The symposium will be a unique opportunity for PhD researchers and postdocs to meet scientists working on these innovative and exciting fields and to see how basic biology discoveries can be converted rapidly into clinical tools in the battle against cancer.
Confirmed speakers: dr. Lukas Chavez, prof. dr. Jo Vandensompele, dr. Maite Huarte, prof. dr. Sven Diederichs, dr. Marc Mansour, prof. dr. François Fuks, prof. dr. Chris Marine, prof. dr. Kim De Keersmaecker, prof. dr. Davide Ruggero, prof. dr. Jonathan Dinman, prof. dr. Giulio Superti-Furga, prof. dr. Chuna Choudhary and prof. dr. Anna Sablina
"Nonparametric estimation of efficiency in the presence of environmental variables"
(sandwiches will be provided)
"Testing for normality in robust regressions"
This conference will bring researchers and clinicians studying T-cell leukemia together. An update will be given on recent advances in the research labs as well as in the clinic. The meeting will consists of keynote lectures given by invited speakers as well as of talks and posters selected from submitted abstracts.
Justice and Priority Setting in Health Care. Intensive Course on Contemporary Ethical Issues regarding Choices in Health Care. 3rd Edition
In the spring of 2017, the Centre for Biomedical Ethics and Law (KU Leuven) organizes the third edition of the successful intensive course ‘Justice and Priority Setting in Health Care’. This course is an excellent occasion to reflect on present and future ethical challenges regarding choices in health care.
The starting point is the fact that contemporary health care systems face many challenges, which essentially boil down to the following question: How can we reconcile (1) the principle of justice and equity for all, with (2) the assignment of providing good quality care, and (3) the principle of economic sustainability? The objective of this intensive course is to analyse the key issues at stake, both from a theoretical perspective and from the perspective of applied ethical questions.
This course works from an interdisciplinary perspective. During the course, an international group of philosophers, economists, theologians, physicians, pharmacologists, psychologists, lawyers, policy makers and health care managers, will focus on the issue of justice and priority setting in health care. There will be time for intensive discussions
Impact of physical and enzymatic modifications on the release of starch and the viscosity forming potential of potato flakes
Dehydrated potato derivatives are manufactured for producing potato-based convenience foods such as instant mashed potatoes and fried potato crisps. Such derivatives are produced by boiling potatoes after steam peeling, mashing and subsequent drying. The remaining products are then sold as drum-dried potato flakes or as air-dried potato granules. They contain cold water swelling starch which readily develops viscosity upon hydration. The potato flakes have a substantial amount of broken cells (40-60%) and extracellular starch. It is believed that these characteristics determine the functionality of potato flakes during processing. The objective of this study was to evaluate the impact of additional cell wall breakdown by ball milling on the release of starch and the viscosity forming potential of potato flakes. First, commercial potato flakes [80% starch on dry matter (dm), 8% protein dm, 3% ash dm and 7% dietary fiber of which 1.7% dm consists of uronic acids] were ball milled for 5, 15, 30 and 60 min. Both the particle size distribution and soluble uronic acid contents were monitored to assess the impact of ball milling on the breakdown of potato cell walls. Mean particle size of potato flakes decreased from 338 µm to 152 µm after 60 min of ball milling while the soluble uronic acid content increased from 1.1% dm to 1.4% dm.Also, a significant increase in extracellular starch content (from 14.7% dm to 19.0% dm) was measured. Chain length distributions of the extracellular starch were determined with Size Exclusion High Performance Liquid Chromatography (SE-HPLC). The increase in extracellular starch was mainly attributed to a higher degree of extraction of amylopectin. Furthermore, the extractability of long amylose chains (degree of polymerisation 2,500-4,500) increased upon ball milling. The swelling and pasting properties of untreated and ball milled potato flakes were evaluated with the Rapid Visco Analyzer (RVA). Peak viscosity values of potato flakes at a dm content of 8% increased from 1,470 mPa.s to 2,260 mPa.s as a result of 60 min ball milling which went hand in hand with an increased swelling power (from 31.2 g/g to 35.3 g/g). Breakdown of potato cell wall material removes the physical barriers limiting the swelling and, hence, viscosity development of the flakes. At the same time, the higher extracellular starch content led to 10% higher end viscosity values due to improved gel formation. We conclude that ball milling improves the swelling properties and gel forming capacity of potato flakes. Higher viscosity development upon hydration of potato flakes can enhance instant structure formation during processing.
KBI - Statistics and econometrics seminar by prof. Mogens Forsgerau (Technical University of Denmark)
"Generalized entropy models"
Title: to be announced (co-authored with Maikel Pellens)
(sandwiches will be provided)